Serum PD-1 Is Elevated after Pembrolizumab Treatment but Has No Predictive Value

Melanoma Brain Metastasis Pseudoprogression after Pembrolizumab Treatment.

The role of immunotherapy in treatment of brain metastases is unknown because most trials exclude patients with active brain lesions. As new immunomodulating agents gain approval for many malignancies, it is important to know if they have unique effects in the central nervous system (CNS). Here, we present a case of a patient with progressing brain metastases treated with a single cycle of pemb...

A moderately elevated day 3 FSH concentration has limited predictive value, especially in younger women.

BACKGROUND A cycle day 3 FSH concentration is a popular screening tool for predicting success in achieving pregnancy after IVF. Difficulties interpreting this test have resulted from lack of consensus in defining an elevated FSH concentration, a change in the assays, and lack of controlling for factors which may confound the association between FSH concentration and pregnancy. METHODS Assessm...

Title: Melanoma brain metastasis pseudoprogression after pembrolizumab treatment Running head: Brain pseudoprogression after pembrolizumab Authors:

But he has no chest pain…

Atypical presentations of acute coronary syndromes (ACS) are not uncommon and have been associated with higher mortality probably, because these patients are misdiagnosed and undertreated. They are most frequently encountered in older patients, women and in patients with diabetes, chronic renal failure or dementia. It is also well described in the literature that many chemotherapy agents are as...

Predictive biomarkers in PD-1/PD-L1 checkpoint blockade immunotherapy.

Checkpoint blockades turn on a new paradigm shift in immunotherapy for cancer. Remarkable clinical efficacy, durable response and low toxicity of programmed death 1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint blockades have been observed in various malignancies. However, a lot of cancer patients failed to respond to the PD-1/PD-L1 checkpoint blockades. It is crucial to identify a biomar...